| ncRNA name | hsa-miR-181b |
| ncRNA Category | miRNA |
| Disease name | uveal melanoma (UM) |
| Species | Homo sapiens |
| Tissues/Cell_line | UM cell lines SP6.5, VUP, OCM1, 92-1, OCM1a and MUM2b |
| Methods | Western blot, luciferase reporter assay, microarray, qRT-PCR, transfection |
| Expression pattern | up-regulated |
| Functional description | miR-181b over-expression inhibited CTDSPL expression, which in turn led to the phosphorylation of RB and an accumulation of the downstream cell cycle effector E2F1, promoting cell cycle progression in UM cells. |
| PubMed ID | 29382357 |
| Year | 2018 |
| Title | The miR-181 family promotes cell cycle by targeting CTDSPL, a phosphatase-like tumor suppressor in uveal melanoma. |
| Drug-related ncRNA | NO |
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